Presumably, Alice and Polly had a good relationship before Polly began dating Jason Blossom, son of a family she despised. When Alice found out about the two she was furious and tried to break them up. She was thrilled when Jason's parents forced him to do so, despite her daughter's heartbreak, damaging her relationship with Polly.
Polly found out she was pregnant by Jason and they resumed their relationship and made plans to run away together and raise the baby because they knew their parents would not approve. On July 4th, the day Polly and Jason were to leave, Alice somehow found out and she and her husband secretly had their daughter forcibly locked away at the Sisters of Quiet Mercy group home for troubled youths and planned for Polly to give the baby up for adoption once he or she was born.
To cover up Polly's pregnancy, Alice and her husband Hal told everyone, including Betty, that Polly had a nervous breakdown when Jason broke up with her, and that was why she was sent to live at a group home.
After being locked up for months by her parents, Polly was found by Betty and Polly told her of her pregnancy and the truth about everything that had happened. Betty realized that their mother had not told Polly that Jason was murdered, so Betty was forced to tell her. However, Alice was notified when Polly received a visitor and angrily came to collect Betty. Before leaving the facility, Alice had a run-in with Polly, who confronted her over Jason's death. Distraught, Polly was pulled away by two orderlies. That night Polly broke the window in her room and escaped the group home.
Determined to find Polly before the Blossoms could, Betty and Jughead Jones organized a search of Eversgreen Forest and instructed a group of volunteers, including Alice and Hal, to scour the woods between the Sisters of Quiet Mercy and the closest bus station, but the search was interrupted by the Blossoms. Afterwards, Alice decided to go all "damage control mode" and addressed the press outside a church that all the rumors about Polly were not true. She even announced the one thing that she wanted to keep secret — Polly was pregnant with Jason Blossom's unborn child.
As Jughead walked Betty home that same night, something he said led Betty to realize where Polly was hiding — the attic of their house. According to Betty, she had hidden there before when she was nine and had had a huge argument with Alice that resulted in a neighborhood search. Betty found her sister who told her that she wanted to raise her baby on a farm upstate like she and Jason had planned, but she had no resources. Polly stayed hidden while Betty figured things out, as Alice and Hal were still insisting that she give the baby up for adoption, they even lied to Betty and told her the adoption was Polly's idea. Betty went to the Blossoms on Polly's behalf but learned from Cheryl that they only wanted Jason's baby and not Polly. As she could not live with her parents, nor the Blossoms, and keep her baby, Polly went to stay at The Pembrooke with Veronica Lodge and her mother.
After learning from Sheriff Keller that Polly was with the Lodges, Alice angrily showed up at the high school to speak with Betty and Veronica. Alice tried to convince Betty that Polly giving up her baby was the best thing she could do, but Betty disagreed and told her mother that Polly keeping her baby was not Alice's choice, only Polly's and that her only choice was whether or not she wanted to be a part of Polly's life going forward. Betty informed her mother of the baby shower she and the Lodge's were planning for Polly, but told her she could only attend if she would be loving and supportive, like a proper grandmother-to-be. Polly was approached by Betty and Veronica with the idea that they'd throw her a baby shower. Initially hesitant, Polly agreed, stating that she wanted her mother there, as well as the Blossoms. While Alice was definitely invited to the shower, it was clear that the chances of her actually attending the event were slim, which left Polly disappointed and Betty attempting to cheer her up.
Unexpectedly, after advice from Hermione, Alice decided to attend the baby shower. While initially hesitant with one another, Alice was glad that Polly was safe, her and the baby, and they shared a hug before Cheryl arrived and interrupted. With Betty's help, Alice behaved herself at the party, though it was difficult for her around Penelope and Cheryl Blossom. She tolerated them, as she was grateful to be there for Polly. During the gift giving a portion of the shower, and Alice gave Polly the night light that she used as a child. Alice had saved it since she knew how much Polly loved it, and how it made her feel safe, so she wanted Polly's child to have it. However, minutes later, the evening came to a close as Alice could no longer contain herself after Cheryl and Penelope invited Polly to stay with them at Thorn Hill. This led to a brief altercation between Alice and Penelope, in which Alice claimed she would not let the Blossoms steal her daughter, she would never set foot in their house. Polly jumped up and yelled at them both, claiming their petty rivalry and refusal to let her and Jason be together is what led to his death before she stormed off in tears.
After the shower, Alice apologized for her outburst, but Polly was still upset at her after being left alone at the Sisters of Quiet Mercy, which was never Alice's intention, she even pleaded with Polly to return home with them. Polly took her offer into consideration, but she couldn't help but wonder if Hal would make another appointment for her, which Alice was clueless About. Apparently, before sending Polly to the Sisters, Hal had made an Appointment for Polly to get an abortion behind Alice's back.
That night, Alice confronted Hal over the appointment he had supposedly made for Polly, which he confirmed he had made. She shoved him in a fit of rage, as Hal did to Polly, exactly what he did to her. She then wondered why sending Polly to the Sisters wasn't enough, to which Hal explained that Polly's life was being ruined by that mistake, as he would not be party to raising a child that had Blossom blood. However, Alice was the intent of Polly moving back in, so, defending her daughter, she screamed at Hal to get out before she did something that they both regretted. The next morning, Alice and Betty awaited Polly's return home, but in a twist of events, Polly took the Blossoms up on their offer to stay at Thornhill, which left Alice and Betty devastated.
To get back at the Blossom family, bring them to heel, Alice declared to Betty and Jughead that she would be writing a searing exposé on the redheaded family. While it may not bring Polly home, it would make Alice feel better. She had heard that the Blossom Maple Farms company board of trustees was descending on Riverdale, much to the suspicion of Alice and she just needed a way in to find out what was happening. Alice was of the opinion that Polly had made her choice but Betty refused to believe that, she just needed a way in. Her way in came in the form of Archie who had attended a Blossom family event with Cheryl. Afterwards, Archie informed Alice and Betty that the Blossoms were treating Polly great and that he did not think she wanted to come back, which Alice was just fine with, or so she claimed. Despite Polly being at Thornhill with the Blossoms, Alice would not allow this to sway her from exposing them, claiming that Polly betrayed them. Story written, Betty went with Alice to publish it in The Register, but Hal was there and had locked her out of the system. She had kicked him out of their house, so he was firing her from their paper. As she and Betty exited the office, Alice was so angry she picked up a large rock and threw it through the front glass door of the Register, screaming "I want my daughter back, you bastard!".
The following night, she learned from Betty and Jughead that Polly had not betrayed them, but that she was actually spying on the Blossoms, making her their woman on the inside. Alice cried as a sign of relief and admitted that when sohe went after the story, a part of her thought that Polly might have been gone forever. Betty assured her Polly would come home.