The relationship between Fred Andrews and Hermione Lodge goes way back while the two were still in high school, the briefest of flings, as Hermione described. When she returned to Riverdale over a decade later, following the arrest of her husband, she and Fred rekindled their romance. However the relationship was ended by Fred the second time after learning that Hermione and Hiram were the anonymous buyers of the SoDale project. Though Hermione appears to care for Fred, and his well-being, she is more interested in securing herself, as well as her relationship with Hiram.
Upon her husband being arrested for embezzlement, Hermione and her daughter Veronica relocated from New York to Hermione's hometown of Riverdale. Seeking employment, Hermione sought out Fred Andrews at his company Andrews Construction, she had noticed on his website that he was in need of a seasonal hire. They briefly discussed their complicated past, before Fred explained that, if it was up to him, he would hire her, however, could not have the wife of Hiram Lodge, currently incarcerated and on trial for fraud and embezzlement, balancing his books.
In an effort to meet with the Southside Serpents to pay them for a job they had done for her husband, decreasing the value of the Twilight Drive-In so that Hiram could purchase it at a cheaper price, Hermione asked Fred to accompany her to closing night at the drive-in, as if would be less conspicuous than her going alone. Hermione and Fred attended in his truck and recalled their senior year there watching Candyman together, where they shared a kiss and the briefest of flings. Shortly afterwards, Hermione excused herself and secretly met with FP Jones, the Serpents leader.
The next morning, as he picked up his order from Pop's, Fred asked Hermione out on a date. Regrettably, she turned him down as they were both married. Fred was under the impression that their outing at the drive-in the night before was date, when in fact it wasn't.
After a rattlesnake in a box was left at the diner late one night, Hermione called Fred for assistance in disposing of it. Once he had done so, Fred remarked that he would always be there for her, but he wondered why she hadn't called the police or animal control, to which Hermione explained that the snake was a message to her from the Southside Serpents and she couldn't call anyone else because she didn't trust the police, or half the people in Riverdale for that matter, only Fred. Hiram owed the Serpents money and while grateful for Fred's help, she couldn't tell him anything else as she did not want to get him any more involved than he already was. The next morning, Fred and Hermione both attended Jason Blossom's Memorial and ran into one another after paying their respects. After the incident that took place at the diner the night before, Fred decided to give Hermione the job as his bookkeeper. Ecstatic, Hermione hugged him.
During Hermione's first day on the job as bookkeeper for Andrews Construction, she made an unsettling discovery, Fred only had enough money in the bank to pay his guys for two more weeks. Fred would be putting his business at risk if he didn't fire some people, but he explained that he was waiting to hear about the bid for the new development of the drive-in, in which the construction for could put him back in the black. However, he didn't know who the buyer was, but since Mayor McCoy was handling all the arrangements for the buyer, Fred figured he'd present her with his bid. Fred asked for Hermione to be his co-host, to which she agreed and also offered to have the diner at her place, since it was nicer. She then playfully touched Fred's chest, which quickly escalated to kissing. Unbeknownst to either of them, Veronica had seen.
As planned, he and Hermione hosted the diner for Mayor McCoy, who agreed with his proposal, however, while she would have liked to award him the contract, the buyer was already in the process of accepting another bid and it would take the signatures of two share holders to stop the process. Feeling for Fred, Hermione approached Veronica the next day with the notion to award Fred the construction contract, as she was named an officer of the company when her father had been imprisoned. However, Veronica, still angry over her mother's kiss with Fred, refused to sign leading Hermione to forge her signature.
Fred sat alongside Hermione at the 75th annual Variety Show as Archie performed on stage. Afterwards, he learned that Andrews construction had been awarded the contract for the new development, and thanked Hermione for being his good luck charm. Hermione congratulated him, however, Veronica was not too happy to hear the news.
To make things right with her daughter, Hermione negotiated an end to their argument after Veronica went on a shopping spree and a party bender to get back at her. Hermione explained that she had feelings for Fred Andrews, but she could not say what it meanst yet, as she did not know herself. As for Hiram, he made his own decisions, which distanced him from Hermione, and now she had to make own decisions about moving forward with her life. She asked Veronica to accept her affair until she got more information. In return, Veronica demanded that whatever was happening between her and Fred couldn't happen at The Pembrooke, and that she'd have to tell Hiram about forging her signature, to which Hermione agreed.
On the day Andrews Construction was supposed to break ground on the SoDale project, Fred suffered a major setback, as his crew quit on him after an offer from Cliff Blossom that they couldn't refuse. The next day, after confronting Cliff, Fred returned to the office and informed Hermione that the Cliff was in a grudge match with the anonymous buyer of the land and, unfortunately, Andrews Construction was caught in the cross-hairs. Worried, Hermione asked Fred if Cliff had told him who the buyer was, if he knew it was actually Hiram, but Cliff didn't, he was just as in the dark as Fred. Moments later, Hermione and Fred received an unexpected surprise in the form of Archie, Jughead, Kevin, and Moose, all of whom had volunteered to assist them in keeping the project on schedule until they could hire a new crew. While initially hesitant, Hermione reminded Fred that desperate times called for desperate measures and Fred welcomed the boys aboard. However, that night, two thugs came onto the site, broke some of the equipment and attacked Moose, who had seen them, and threatened to come back if construction wasn't halted.
The next day, as Hermione put in calls to Centerville and Greendale for a new construction crew, Fred remarked that in the meantime, she and him would just have to be a two-person crew. However, much to their surprise, FP Jones was already on site, along with several other Serpents, all willing to work. FP assured Fred that with his guys working for Fred there wouldn't be anymore trouble. As Fred went to get the Serpents settled, Hermione was informed by FP that the two thugs that attacked Moose and destroyed the equipment weren't local, they were from Montréal and they both knew who had business up in Montréal, Hiram. He had caught wind of Hermione's affair with Fred, and sent the two men as a warning.
Speaking with Veronica, Hermione revealed that between Hiram finding out about Hermione's secret affair with Fred and the Blossoms still fighting for the land development, Hermione was under a lot of stress and pressure, not to mention that fact that Fred was still unaware that Hiram was the anonymous buyer. Veronica suggested that she tell Fred the truth before someone else did, even if it meant risking the SoDale project.
Following her conversation with Veronica, Hermione decided to tell Fred the truth, that she and Hiram were the anonymous buyers, a revelation that Fred did not take well. Fred exploded as she attempted to explain her reasons for deceiving him; had she told him the truth, he never would have gotten involved, which Fred agreed with as he did not do business with criminals. Hermione was attempting to turn Lodge Industries legitimate, but she could only do that by partnering with businesses like Andrews Construction. Fred realized that Hermione's lies were the reason that Cliff Blossom stole his crew and sent thugs to beat up teenagers, which Hermione divulged wasn't entirely true. It was Hiram who sent the thugs after learning from Cliff about their affair, which enraged him even more that he was caught in a war between Cliff and Hiram. Hermione understood that Fred was angry, but she pleaded with him to stay on the project because she would not be able to start over if Fred abandoned it. Fred refused to do the grunt work while Hiram was taking shots at him and Hermione played both sides, so he exited the trailer.
A couple days later, Hermione went to Fred and announced that she had decided to sell the SoDale project to Cliff before it got any worse. However, after having some time to think on it, Fred decided to stay with the project, much to Hermione's happiness, but he had several terms that Hermione would first have to agree to. Fred informed her that everything they would do from that point forward would be legal, and that his stake would be 20%, a percentage he was not willing to negotiate on. If he was going to put himself on the line, then he was going to need some insurance, he was tired of seeing people like the Lodges and the Blossoms using his family as pawns. And finally, Fred ended their romantic relationship, stating that moving forward they would be nothing more than business partners, much to Hermione's distress.