|“||I, Clifford Cochrane Blossom, being of sound mind and body, do here inscribe the terms of my last will and testament. Firstly, ownership of Thistlehouse will stay with our beloved matriarch, Roseanne Blossom.||”|
|— Cliff Blossom's Will-Reading[src]|
Thistlehouse is the current residing place of Cheryl and Rose Blossom after their old family residence, Thornhill, was set ablaze and destroyed by Cheryl. Since then, Claudius Blossom had returned to Riverdale, taking up residence in Thistlehouse. Some time later, Cheryl was able to separate herself and Rose from Penelope and Claudius, who were plotting against them. Penelope and Claudius no longer live in Thistlehouse.
- "Chapter Fifteen: Nighthawks"
- "Chapter Nineteen: Death Proof"
- "Chapter Twenty: Tales from the Darkside"
- "Chapter Twenty-Two: Silent Night, Deadly Night"
- "Chapter Twenty-Three: The Blackboard Jungle"
- "Chapter Twenty-Six: The Tell-Tale Heart"
- "Chapter Twenty-Seven: The Hills Have Eyes"
- "Chapter Twenty-Eight: There Will Be Blood"
- "Chapter Twenty-Nine: Primary Colors"
- "Chapter Thirty: The Noose Tightens"
- "Chapter Thirty-One: A Night to Remember"
- "Chapter Thirty-Two: Prisoners"
- "Chapter Thirty-Three: Shadow of a Doubt"
- "Chapter Thirty-Four: Judgment Night"
- "Chapter Thirty-Five: Brave New World"
- The filming location for Thistlehouse is the Foxglove Farm in Langley, British Columbia, Canada.
- In "Chapter Twenty-Two: Silent Night, Deadly Night", a replica of The Nightmare, a 1781 oil painting by Anglo-Swiss artist Henry Fuseli, hangs above the fireplace.